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> Manganese blocks HIV replication, and Colloidal Silver HIV tests

Freedom Fighter
Group: Members
Posts: 783
Member No.: 114

Posted: Jun 8 2004, 10:17 PM
Quote Post
This information was very kindly supplied by Jim Phelps,
who also wrote the "air pharmacology" essay,
that I posted on the Oak Ridge scientist identifying the chemtrail proofs of the fluoride maetals complex and health.
Much more will be posted on that thread as well soon.

Manganese blocks HIV replication; Lab finding points to potential new class
of HIV treatments

Johns Hopkins scientists have found that simply increasing manganese in cells can halt HIV's unusual ability to process its genetic information backwards,
providing a new way to target the process's key driver, an enzyme called reverse transcriptase.
By measuring DNA produced by a related reverse transcriptase in yeast, the
Hopkins team discovered that higher than normal levels of manganese, caused by a defective gene, dramatically lowered the enzyme's activity
. The scientists then proved that HIV's reverse transcriptase responds to manganese in the same way.

Hopkins graduate student Eric Bolton determined that the defective gene is PMR1,
whose protein carries both manganese and calcium out of cells.
Using special yeast developed by others at Hopkins, he discovered that manganese stops reverse transcriptase, the team reports in the April 26 issue of Molecular

"These results really point to a never-before-proposed way to try to stop HIV in its tracks -- that simply manipulating concentrations of a metal,
manganese, can have a profound effect on reverse transcriptase," says Jef Boeke, Ph.D., professor of molecular biology and genetics at the school's Institute
for Basic Biomedical Sciences.
"We expect the human equivalent of PMR1 could be a
good target for developing new drugs against HIV."

snipped----see URL for more


Is there a simple, inexpensive treatment for AIDS? Perhaps so. An obscure but crucial discovery was made at the Biochemsitry Unit of Upjohn
Labboratories in 1991:
"Among a number of metal ions tested, Zn2+ (zinc), Cn2+ (copper), and Ag1+ (silver) were found to be the most effective inhibitors of renin and the
HIV protease (data not shown). Kenectic analysis revealed that inhibition of
renin by Ag1+ (silver) is basically identical with that seen with Zn2+ (zinc),
i.e., concompetitive, first order with respect to the metal." Biochemistry, September 10, 1991.

Further testing at Upjohn, including a clinical trial, revealed that zinc was toxic in effective dosages. This was the first report that silver is a
highly effective protease inhibitor.

A year later, this same discovery was made at the University Medical Center in Geneva, Switzerland:
"Metal-binding proteins are important components of retroviruses such as human immunodeficiency virus (HIV). Therefore, metals could be used as
antiviral agents...silver is a highly active bacteriacidal metal with little toxicity for humans.
Silver has also been shown to be a potent inhibitor of
HIV protease." Biochemical and Biophysical Research Communications, December 30, 1992.
Three years later, Temple University in Philadelphia, Pennsylvania, USA,
made this same discovery apparently independently:
"We tested the ability of biotic silver protein to inhibit human immunodeficiency virus type 1 (HIV-1) replication in the human T cell line, SupT 1,
as measured by syncytia formation. We found that pure silver protein inhibited HIV-1 replication in SupT 1 cells as measured by a reduction in the appearance
syncytia in cell culture. There appeared to be little if any acute toxicity
associated with the dose of biotic silver protein which inhibited HIV-1
replication...These results are very encouraging and suggest additional experiments that could be done..." Earl E. Henderson, Ph.D. Professor.

The following March 20, 1995, Professor Earl E. Henderson released the findings of another experiment at Temple University:
"My laboratory has studied the effects of special formulation of biotic silver protein on human immunodeficiency virus Type 1 (HIV-1) survival and on
latency reactiviation of HIV-1 in the human lymphoblastoid B cell line,
M57-3...The results of the...experiment show that exposure of HIV-1 to 1000 ppm of
special formulation of silver protein
for one hour at 37 degrees Centigrade
completely eliminates infectious HIV-1 as measured by syncytia formation on SupT
1 cells..." >>

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